Home Health News Clearing the smoke: 5 interesting findings from a deep dive into cannabis studies

Clearing the smoke: 5 interesting findings from a deep dive into cannabis studies

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Despite being consumed by people for hundreds of years, cannabis stays a considerably mysterious plant. The similar joint which will ease one person into a soothing state of euphoria might jolt one other into a hellish panic assault.

Complicating issues is the plant’s outlaw standing. It stays federally unlawful in the United States, deemed a Schedule 1 substance in the similar class as heroin, requiring particular permission from the Drug Enforcement Agency (DEA) to make use of in studies.

Despite the U.S. federal authorities’s strict stance, a number of American states have gone rogue and permitted leisure use, and much more states are contemplating it.

Canada will legalize leisure use nation-wide on October 17 and a number of other different nations like Chile, Italy, Jamaica, Argentina, Uruguay, and Colombia, have both decriminalized or legalized each medical and leisure use.

With many elements of the world shifting away from criminalizing cannabis, studies associated to the plant at the moment are being often performed, with typically shocking and contradictory outcomes.

As a part of our Marijuana Files protection, MetropolisNews has delved into the wealth of established and rising analysis on the subject. Here’s 5 interesting takeaways from our deep dive into marijuana, with hyperlinks to 50 studies that shed new gentle on the bodily, psychological, and societal results of cannabis consumption. (Click the title for hyperlinks)

1. Marijuana could help regulate your weight

For some, marijuana is synonymous with the munchies. The drug’s appetite-stimulating properties are the butt of numerous stoner jokes. But it’s no laughing matter for individuals struggling from losing sicknesses, or going by way of chemotherapy remedies. So, does marijuana actually trigger weight acquire? A 2014 report by Innovations in Clinical Neuroscience discovered that marijuana could certainly stimulate the urge for food and support in weight acquire for individuals struggling from sicknesses or present process most cancers remedies, however in the basic inhabitants, cannabis use is definitely related to a decrease physique mass index. The takeaway: Marijuana could assist regulate a healthy physique weight. “Marijuana may genuinely be a regulatory compound, increasing weight in those with low weight, but not in those who are normal or overweight,” the examine concludes.

2. Marijuana use has negligible effect on crime

Back in the Reefer Madness days, residents have been led to consider that a single toke of marijuana had the potential to remodel a previously law-abiding citizen into a raging, homicidal maniac. That sensational depiction could have been debunked, however there are nonetheless issues that marijuana will result in extra crime. Not so, says a 2018 examine by Victoria University of Wellington and Motu Economic and Public Policy Research. In reality, they discovered that violent crimes and property crimes fell by 20 per cent in California after the state permitted medical marijuana utilization. “We also find no evidence that heavy marijuana users commit property crime to fund addictions,” the examine concluded. “Our outcomes recommend that liberalization of marijuana legal guidelines is unlikely to lead to the substantial social value that some politicians clearly concern.

3. Weed won’t turn you in Michael Phelps

Olympic swimming sensation Michael Phelps could also be certainly one of the biggest athletes ever known to hit the bong, however don’t anticipate your personal weed smoking habits to guide you to Olympic glory. That’s the conclusion from a examine by the Clinical Journal of Sport Medicine. It discovered “no evidence of performance-enhancing” results when it got here to athletes and weed. But marijuana might assist athletes in numerous methods. “Cannabis use has also recently been identified as helping athlete’s sleep time and recovery, which may favor performance when an athlete is facing multiple competitions in a short period,” the examine notes.

4. More weed, more sex?

So we’ve established that weed gained’t make you a higher athlete, however it might make you extra energetic between the sheets based on analysis by The Journal of Sexual Medicine. It got down to examine if there was a relationship between marijuana use and sexual frequency. Despite the stereotype that stoners are lazy, they appear to be fairly energetic in the case of intercourse. The examine’s conclusion: “A positive association between marijuana use and sexual frequency is seen in men and women across all demographic groups.”

5. Potential treatment for autism?

Can cannabis assist deal with autism spectrum dysfunction (ASD)? A examine revealed in the journal Neurology sought to seek out out if compounds present in the cannabis plant might enhance behavioural issues in kids with autism. In the examine, 60 kids with autism have been handled with oral CBD and TCH at a ratio of 20:1. The outcomes have been promising. Behavioral outbreaks, nervousness and communication issues, and disruptive behaviors have been all markedly improved. Conclusion: “This preliminary study supports the feasibility of CBD based medical cannabis as a promising treatment option for refractory behavioral problems in children with ASD.”

More marijuana studies:

6. Gone to Pot – A Review of the Association between Cannabis and Psychosis

In people with a longtime psychotic dysfunction, cannabinoids can exacerbate signs, set off relapse, and have detrimental penalties on the course of the sickness. Several elements seem to average these associations, together with household historical past, genetic elements, historical past of childhood abuse, and the age at onset of cannabis use. Exposure to cannabinoids in adolescence confers a greater threat for psychosis outcomes in later life and the threat is dose-related.

7. Cannabinoids and psychosis

Cannabinoids can induce acute transient psychotic signs or an acute psychosis in some people. What makes some people weak to cannabinoid-related psychosis is unclear. Also clear is that cannabinoids may exacerbate psychosis in people with a longtime psychotic dysfunction, and these exacerbations could final past the interval of intoxication. Less clear is whether or not cannabis causes a persistent de novo psychosis.

8. Opposite Cannabis-Cognition Associations in Psychotic Patients Depending on Family History

In a pattern of 268 first-episode psychosis sufferers and 237 controls. We discovered that cannabis use was related to worse working reminiscence, no matter household historical past. However, cannabis use was clearly related to worse cognitive efficiency in sufferers with no household historical past of psychosis, in cognitive domains together with verbal reminiscence, government perform and world cognitive index, whereas cannabis customers with a household historical past of psychosis carried out higher in these domains.

9. Effects of marijuana on memory

Working Memory Paradigm: A Meta-Analysis of Normative Functional Neuroimaging Studies the n-back job, through which topics are requested to observe the identification or location of a collection of verbal or nonverbal stimuli and to point when the at the moment introduced stimulus is the similar as the one introduced n trials beforehand. We performed a quantitative meta-analysis of 668 units of activation coordinates in Talairach house reported in 24 major studies of n-back job variants manipulating course of (location vs. identification monitoring) and content material (verbal or nonverbal) of working reminiscence.

10. Affect and cannabis use in daily life: a review and recommendations for future research

Findings assist a detrimental reinforcement speculation for scientific samples when it comes to basic NA and anger/hostility. However, discrepancies amongst studies level to a have to completely characterize samples, think about motives for and expectations of use, enhance quantification of cannabis use, and think about co-use with different substances. Additional design suggestions are additionally provided for future studies.

11. Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science.

There is accumulating proof for varied therapeutic advantages of cannabis/cannabinoids, particularly in the remedy of ache, which can additionally apply to the remedy of migraine and headache. There can also be supporting proof that cannabis could help in opioid detoxing and weaning, thus making it a potential weapon in battling the opioid epidemic.

12. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.

Abstract: Cannabis use is a heritable trait that has been related to antagonistic psychological health outcomes. In the largest genome-wide affiliation examine (GWAS) for lifetime cannabis use to this point (N = 184,765), we recognized eight genome-wide vital unbiased single nucleotide polymorphisms in six areas.

13. A Modern Conundrum for the Pediatrician: The Safety of Breast Milk and the Cannabis-Using Mother

Despite this cautionary proof, cannabis is now the mostly reported leisure drug utilized by pregnant and lactating ladies. Up to 36% of ladies report having used marijuana sooner or later of their pregnancy, and 18% report having used it whereas breastfeeding.2 These excessive charges of reported use increase necessary points for these medical suppliers who present care to infants and youngsters or who could also be requested by mother and father about the security of marijuana use throughout lactation

14. Cannabidiol for Epilepsy: New Hope on the Horizon?

There has been an infinite curiosity in creating antiepileptic medicine with novel mechanisms of motion. This assessment discusses the proof supporting the anticonvulsant properties of cannabis in people, specializing in cannabidiol.

15. Development of simple and accurate detection systems for Cannabis sativa using DNA chromatography 

This examine was aimed to determine a easy and correct cannabis DNA detection system utilizing DNA chromatography.

16. Adverse Effects of Cannabis on Male Reproduction

Abstract: The use of cannabis use is more likely to improve as laws on its consumption are diminishing all through the world. Coinciding with a rise in the use of cannabis is an statement that semen high quality seems to be declining in developed nations, and {couples} are delaying conception extra usually than earlier generations

17. Motives for and impairment associated with alcohol and marijuana use among college students

Analyses indicated that amongst alcohol-only customers, social motives predicted extra alcohol use, whereas amongst twin customers, enhancement motives predicted extra alcohol and marijuana use and impairment. Coping motives predicted extra marijuana use amongst twin customers, however no more alcohol use. Frequency of alcohol and marijuana use predicted extra impairment throughout each the alcohol-only and twin customers

18. Leveraging methodology from research on tobacco, alcohol, and opioid analgesics to make rapid and policy-relevant advances in cannabis science

The legalization of medical and leisure cannabis use has occurred forward of science. The present proof base has poor utility for figuring out if cannabis merchandise can meet the requirements of security, efficacy, and high quality intrinsic to trendy medication, and for informing regulation of cannabis as a authorized intoxicant.

19. Comparing medical and recreational cannabis use among employees: associations with health and work-related outcomes

Nearly one in 5 US workers reviews having used cannabis in the previous yr. As insurance policies and legal guidelines concerning cannabis use quickly change, issues have arisen over workers’ use of cannabis, for each medical and leisure functions.

20. Marijuana Use, Marijuana Expectancies, and Hypersexuality among College Students

The present examine examined hyperlinks between marijuana lifetime use and hypersexuality amongst college college students

21. Marijuana use and risky sexual behavior among high-risk adolescents: trajectories, risk factors, and event-level relationships

Adolescents concerned with the juvenile justice system have a excessive incidence of dangerous sexual behaviors leading to unintended pregnancy and sexually transmitted infections. Substance use could also be significantly necessary as a threat issue for unsafe sexual habits for this group, and up to date proof suggests a potential affiliation between marijuana use and dangerous sexual habits.

22. Relative influence of perceived peer and family substance use on adolescent alcohol, cigarette, and marijuana use across middle and high school

This examine examined developments in concordance of adolescent cigarette, alcohol and marijuana use and corresponding perceived use by family and friends members throughout center and highschool.

23. Fast extraction of cannabinoids in marijuana samples by using hard-cap espresso machines

A easy, fast and low value process was developed for the extraction of Δ9-tetrahydrocannabinol, cannabidiol, and cannabinol from marijuana samples, based mostly on the use of a hard-cap espresso extraction with 2-propanol.

24. The potential of near infrared spectroscopy to estimate the content of cannabinoids in Cannabis sativa L.: A comparative study

The purpose of the present analysis was to develop a quick, economical, sturdy and environmentally pleasant technique based mostly on NIR expertise that permit the quantification of the fundamental cannabinoids present in Cannabis sativa

25. An epidemiological, developmental and clinical overview of cannabis use during pregnancy

Cannabis use in pregnancy poses main health issues for pregnant moms and their creating kids. Although studies on the short- and long-term penalties of prenatal cannabis publicity are rising, findings have been inconsistent or tough to interpret as a consequence of methodological points.

26. Cannabis in liver disorders: a friend or a foe?

In this assessment, we consider the accessible proof on cannabis and its constituents and the software of this proof in scientific observe, focusing significantly on the liver and liver illnesses.

27. Exploring cannabis concentrates on the legal market: User profiles, product strength, and health-related outcomes

Concentrate customers endorsed greater signs of cannabis use dysfunction and use greater strength cannabis even when utilizing non-concentrated kinds. Frequent use of concentrates could also be related to extra dangers over and above frequent use of flower kinds.

28. The association between physical pain and cannabis use in daily life: An experience sampling method.

Experiences of ache are usually not related to choices about whether or not or to not use cannabis. Once cannabis customers are in cannabis-using conditions, they have a tendency to make use of bigger quantities when they’re experiencing elevated ranges of ache. This could have implications for cannabis abuse remedy as ache could make it tougher for customers to scale back their consumption.

29. Ability to monitor driving under the influence of marijuana among non-fatal motor-vehicle crashes: An evaluation of the Colorado electronic accident reporting system.

States, together with Colorado, might think about standardization of drug testing and obligatory reporting insurance policies for drivers concerned in motor-vehicle crashes and proactively tackle the slender window of time for pattern assortment to enhance DUI of marijuana surveillance. Practical purposes: The analysis of state motor-vehicle crash methods’ capacity to seize crashes involving drug impaired driving (DUID) is a vital first step for figuring out frequency and threat elements for crashes associated to DUID.

30. Acute renal (kidney) infarction induced by heavy marijuana smoking

Acute renal infarction often happens in sufferers with extreme atherosclerosis or valvular coronary heart illness. We right here report a 42-year Saudi male who introduced with extreme stomach ache nausea and vomiting related to hematuria, after heavy smoking of marijuana.

31. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Cannabis use is a heritable trait that has been related to antagonistic psychological health outcomes. In the largest genome-wide affiliation examine (GWAS) for lifetime cannabis use to this point (N = 184,765), we recognized eight genome-wide vital unbiased single nucleotide polymorphisms in six areas.

32. Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk

CONCLUSIONS: 9-THC was measurable in a majority of breast milk samples as much as 6 days after maternal marijuana use.

33. Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes

Marijuana is certainly one of the most generally used substances throughout pregnancy in the United States. Emerging information on the capacity of cannabinoids to cross the placenta and have an effect on the improvement of the fetus increase issues about each pregnancy outcomes and long-term penalties for the toddler or little one.

34. Development of simple and accurate detection systems for Cannabis sativa using DNA chromatography

This examine was aimed to determine a easy and correct cannabis DNA detection system utilizing DNA chromatography. Two chromatography chip methods with completely different options have been efficiently developed

35. Cannabinoid concentrations in blood and urine after smoking cannabidiol joints

In this examine, we investigated cannabinoid blood and urine concentrations of a naive consumer and of a modeled continual consumer after smoking a single CBD joint. Chronic use was modeled as smoking 2 joints per day for 10 days.

36. Adverse Effects of Cannabis on Male Reproduction

The use of cannabis use is more likely to improve as laws on its consumption are diminishing all through the world. Coinciding with a rise in the use of cannabis is an statement that semen high quality seems to be declining in developed nations, and {couples} are delaying conception extra usually than earlier generations.

37. Long-term consequences of adolescent cannabis exposure on the development of cognition, brain structure and function: an overview of animal and human research

Evidence from each animal and human studies means that the severity of the results of cannabis use on cognitive improvement relies on the age when cannabis use begins. One potential rationalization is that those that start cannabis use early in adolescence usually tend to grow to be closely dependent.

38. Gender-specific relationships between depressive symptoms, marijuana use, parental communication and risky sexual behavior in adolescence

A big physique of analysis has recognized correlates of dangerous sexual habits, with depressive signs and marijuana use amongst the most constant psycho-social predictors of sexual threat

39. Cannabinoid concentrations in blood and urine after smoking cannabidiol joints

In Switzerland, the sale of cannabis with tetrahydrocannabinol (THC) content material lower than 1% has lately been legalized. As a consequence, cannabis with low THC and excessive cannabidiol (CBD) values as much as roughly 25% is legally accessible on the market. In this examine, we investigated cannabinoid blood and urine concentrations of a naive consumer and of a modeled continual consumer after smoking a single CBD joint.

40. Cannabis use and mental health in young people: cohort study

OBJECTIVE: To decide whether or not cannabis use in adolescence predisposes to greater charges

41. Assessing the effects of medical marijuana laws on marijuana use: the devil is in the details

This paper sheds gentle on earlier inconsistencies recognized in the literature concerning the relationship between medical marijuana legal guidelines (MMLs) and leisure marijuana use by intently analyzing the significance of coverage dimensions (registration necessities, dwelling cultivation, dispensaries) and the timing of when explicit coverage dimensions are enacted.

42. Prevalence of marijuana and other substance use before and after Washington State’s change from legal medical marijuana to legal medical and nonmedical marijuana: Cohort comparisons in a sample of adolescents.

This exploratory examine discovered that marijuana use was extra prevalent amongst teenagers shortly after the transition from medical marijuana legalization solely to medical and nonmedical marijuana legalization, though the distinction between cohorts was not statistically vital.

43. Marijuana Use, Recent Marijuana Initiation, and Progression to Marijuana Use Disorder Among Young Male and Female Adolescents Aged 12-14 Living in US Households

Our examine used 2005-2014 information from the annual, cross-sectional National Survey on Drug Use and Health to review the prevalence and correlates of marijuana initiation, use, and marijuana use dysfunction (MUD; abuse or dependence) amongst 12- to 14-year olds dwelling in civilian US households (n = 84 954). Examined correlates included age, intercourse, race/ethnicity, poverty standing, metropolitan standing, yr of survey, depression, tobacco use, alcohol use, and preventing in school.

44. Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials

Since the discovery of the involvement of the endocannabinoid (eCB) system in emotional reminiscence processing, pharmacological manipulation of eCB signaling has grow to be a therapeutic chance for the remedy of PTSD.

45. Effect of Vaporized Cannabis on Exertional Breathlessness and Exercise Endurance in Advanced COPD: A Randomized Controlled Trial.

Single-dose inhalation of vaporized cannabis had no clinically significant constructive or detrimental impact on airway perform, exertional breathlessness and exercise endurance in adults with superior COPD.

46. The effects of medical marijuana laws on cannabis-involved driving

This examine makes use of information from the Fatality Analysis Reporting System and a differences-in-differences mannequin to look at the impact of state medical marijuana legal guidelines (MMLs) on cannabis-involved driving amongst U.S.

47. Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels

Cannabidiol (CBD) is a compound of Cannabis sativa with related therapeutic potential in a number of neuropsychiatric problems together with depression. CBD remedy has proven vital antidepressant-like results in numerous rodent preclinical fashions. However, the mechanisms concerned in CBD-induced antidepressant results are nonetheless poorly understood.

48. Prevalence and associated birth outcomes of co-use of Cannabis and tobacco cigarettes during pregnancy

Use of Cannabis and use of tobacco overlap, and co-use of Cannabis and tobacco has elevated over the previous decade amongst adults. The present examine goals to doc the prevalence and correlates of co-use of Cannabis and tobacco cigarettes amongst grownup pregnant ladies.

49. Associations Between Marijuana Use and Involuntary Job Loss in US-representative longitudinal and cross-sectional samples

OBJECTIVE: To examine whether or not marijuana use is related to involuntary job loss.

50. Associations between marijuana use and tobacco cessation outcomes in young adults.

Marijuana and tobacco co-use is frequent amongst younger adults, and findings are combined concerning the affiliation between marijuana use and smoking cessation outcomes. This examine examined the longitudinal relationships between marijuana use and smoking cessation outcomes amongst younger adults.

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