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New Vaccine Might Stop COVID-19 Variants and Future Pandemics

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At a time when 35 percent of eligible adults have been absolutely vaccinated towards COVID-19 and the U.S. authorities is providing free Uber and Lyft rides to vaccination websites, there are researchers who’re centered on what comes subsequent. A brand new vaccine developed by the Duke Human Vaccine Institute may assist battle COVID-19 and its variants. It is also the answer we’d like for future pandemics.

 

 

Introducing a New Type of Vaccine

The new vaccine, given solely to monkeys and mice to date, makes use of a nanoparticle to set off neutralizing antibodies. Called a pan-coronavirus vaccine, it’s blocked 100 p.c of COVID-19 infections in monkeys whereas outperforming different present vaccine platforms in assessments.

“We began this work last spring with the understanding that, like all viruses, mutations would occur in the SARS-CoV-2 virus, which causes COVID-19,” Barton F. Haynes, M.D., director of the Duke Human Vaccine Institute (DHVI) informed Nature.

The concept behind the brand new vaccine is that it exploits a weak spot in coronaviruses, a receptor-binding area on the spike that hyperlinks viruses to receptors in human cells. While that binding web site permits the coronavirus to enter a body and trigger an infection, it will also be made a goal for antibodies.

“This approach not only provided protection against SARS-CoV-2, but the antibodies induced by the vaccine also neutralized variants of concern that originated in the United Kingdom, South Africa and Brazil,” mentioned Haynes. “And the induced antibodies reacted with quite a large panel of coronaviruses.”

Haynes believes that what they’ve realized making the vaccine may assist defend towards future illness occasions.

“There have been three coronavirus epidemics in the past 20 years. So, there is a need to develop effective vaccines that can target these pathogens prior to the next pandemic. This work represents a platform that could prevent, rapidly temper, or extinguish a pandemic.”

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