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Taking Fish Oil May Reduce Antibiotic Resistance

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Omega-3 Fish Oil Capsules

For the primary time, Australian scientists have confirmed a link between the function of standard fish oil to interrupt down the power of ‘superbugs’ to change into proof against antibiotics.

The discovery, led by Flinders University and simply revealed in worldwide journal mBio, discovered that the antimicrobial powers of fish oil fatty acids may show a easy and protected dietary complement for folks to take with antibiotics to make their combat towards an infection more practical.

“Importantly, our studies indicate that a major antibiotic resistance mechanism in cells can be negatively impacted by the uptake of omega-3 dietary lipids,” says microbiologist Dr. Bart Eijkelkamp, who leads the Bacterial Host Adaptation Research Lab at Flinders University.

“In the experiments, and complementary supercomputer modeling, we found that these fatty acids in fish oil renders the bacteria more susceptible to various common antibiotics.”

“This chink in the armor of harmful bacteria is an important step forward in combatting the rise of superbugs that are developing multidrug resistance to antibiotics,” says co-author Associate Professor Megan O’Mara, from the Australian National University.

Bart Eijkelkamp

Dr. Bart Eijkelkamp, left, and researchers Felice Adams and Maoge Zang on the Bacterial Host Adaptation Research Laboratory at Flinders University, South Australia. Credit: Flinders University

The analysis is significant within the discipline of infectious illnesses attributable to micro organism equivalent to Acinetobacter baumannii, a number one hospital-acquired pathogen with unprecedented ranges of antibiotic resistance world wide.

“With the rise of superbugs, we have now been able to show that greedy bacterium cannot distinguish between ‘good and bad’ host fatty acids and will consume all of these during an infection,” says one other co-author Dr. Felise Adams, from Flinders University.

“Our research showed that fish oil fatty acids become part of the bacteria membrane and thus make the invading bacteria membrane more permeable and susceptible to the antibiotics being used to attack it.”

“We know Acinetobacter baumannii is one of the world’s most notorious multidrug-resistant pathogens, yet how it responds to host-mediated stress is poorly understood.”

“These studies provide new insights into the potential benefits of omega-3 supplements for bacterial infection, in particular during antibiotic treatment,” says Professor Anton Peleg, director of the Department of Infectious Diseases at The Alfred Hospital, Melbourne.

References:

“To make or take: bacterial lipid homeostasis during infection” by Felise G Adams, Claudia Trappetti, Jack Okay Waters, Maoge Zang, Erin B Brazel, James C Paton, Marten F Snel and Bart A Eijkelkamp, 9 June 2021, mBio.
DOI: 10.1128/mBio.00928-21

“The membrane composition defines the spatial organisation and function of a major Acinetobacter baumannii drug efflux system” by Maoge Zang, Hugo MacDermott-Opeskin, Felise G Adams, Varsha Naidu, Jack Okay Waters, Ashley B Carey, Alex Ashenden, Kimberley T McLean, Erin B Brazel , Jhih Hang Jiang, Alessandra Panizza, Claudia Trappetti, James C Paton, Anton Y Peleg, Ingo Köper, Ian T Paulsen, Karl A Hassan, Megan L O’Mara and Bart A Eijkelkamp, 9 June 20201, mBio.
DOI: 10.1128/mBio.01070-21

The two analysis publications function collaborators from ANU, Macquarie University, University of Adelaide, Monash University, University of Newcastle and the SA Health and Medical Research Institute (SAHMRI), with funding from NHMRC Project Grants 1140554 to MLO and 1159752 and supporting collaborations.



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