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Marijuana use associated with faster kidney function decline in patients with CKD

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SAN DIEGO — Patients with baseline chronic kidney disease who used marijuana skilled extra speedy eGFR decline, in keeping with information offered on the ASN Kidney Week 2018.

“It is important to study marijuana in light of the fact of global legalization and increasing usage,” Joshua L. Rein, DO, from Icahn School of Medicine at Mount Sinai, informed Healio Nephrology. “It is important to know its effects on kidney disease.”

Rein and colleagues analyzed information from the ASSESS-AKI parallel matched cohort research to research whether or not marijuana use was associated with kidney function decline and albuminuria. A complete of 1,599 hospitalized adults who offered to one in every of 4 facilities in the United States between 2009 to 2015 with or with out AKI had been included in the evaluation. Of these patients, 113 (7%) had been marijuana customers. Marijuana customers had been outlined as those that reported utilizing marijuana since their final research go to. Participants had been adopted for a median of 4.1 years.

Marijuana users had been extra more likely to be youthful (imply age, 54 vs. 65 years), white (78%), males (78%) and heavy tobacco customers, which was outlined as smoking 20 or extra cigarettes per day (26% vs. 8%).

Data indicated marijuana customers had a better baseline eGFR than non-users (87 ± 30 mL/min/1.73 m² vs. 69 ± 26 mL/min/1.73 m²); nevertheless, baseline UACR was related among the many two teams (120 ± 80 in customers vs. 99 ± 72 in non-users).

Marijuana use was not linked to incident CKD (adjusted HR = 0.93; 95% CI, 0.5-1.8) or variations in eGFR slope over time (imply distinction, -0.12 mL/min/1.73 m² per 12 months amongst individuals with a baseline eGFR of 60 mL/min/1.73 m² or extra). Conversely, eGFR declined extra quickly amongst marijuana customers with a baseline eGFR of lower than 60 mL/min/1.73 m² in contrast with non-users (-3.2 vs. -1.4 mL/min/1.73 m² per 12 months). Marijuana customers with a baseline eGFR of lower than 60 mL/min/1.73 m² additionally had a better threat for CKD development (aHR = 2.7; 95% CI, 0.83-8.5).

Among individuals with vs. with out CKD, marijuana use was not correlated with the speed of change in UACR.

“In this study, we saw that patients with baseline kidney disease who used marijuana had accelerated decline in their renal function compared to people who did not use marijuana,” Rein mentioned. “Renal function in marijuana users with kidney disease should be closely monitored. We don’t know the reason for the decline in kidney function. I hypothesize it’s because of smoke inhalation. Medical marijuana in the form of vaporization or edibles may not share these same harms.”

“Patients with kidney disease experience significant symptom burden, such as nausea, anorexia and chronic pain, which are all valid issues for medical marijuana usage,” he continued. “If patients with kidney disease are prescribed marijuana for their symptoms, we need to be mindful of the effects on the kidney.” – by Alaina Tedesco

 

Reference:

Rein JL, et al. Abstract FR-PO233. Presented at: ASN Kidney Week; Oct. 23-28, 2018; San Diego.

 

Disclosure: Healio Nephrology was unable to substantiate related monetary disclosures on the time of publication.



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