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Potential COVID-19 antiviral drug being tested in humans after proving effective in hamster study

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A possible COVID-19 antiviral drug is displaying early promise and effectiveness in hamsters, in line with a brand new study from the National Institutes of Health.

Results revealed that the experimental antiviral drug MK-4482 “significantly decreased levels of virus and disease damage in the lungs of hamsters treated for SARS-CoV-2 infection,” in line with a statement.

The experimental drug, delivered solely orally, is now being tested in human scientific trials by Ridgeback Biotherapeutics and pharmaceutical firm Merck. Remdesivir, a unique antiviral drug already accredited by the U.S. Food and Drug Administration, can solely be supplied intravenously.

Scientists mentioned they discovered MK-4482 proved to be effective when given as much as 12 hours earlier than, or 12 hours after, the hamsters had been injected with the coronavirus. 

RELATED: Pfizer begins phase 1 study of oral COVID-19 treatment drug

The newest study concerned three teams of hamsters: a pre-infection remedy group, a post-infection remedy group and an untreated management group. For the 2 remedy teams, scientists gave the hamsters MK-4482 orally each 12 hours for 3 days. Results confirmed the hamsters had 100 instances much less infectious virus in their lungs than the management group and had fewer lesions in the lungs than the management group.

The U.S. Food and Drug Administration has solely fully approved Remdesivir, an antiviral agent, for COVID-19 remedy. It is beneficial for sufferers in a hospital who require supplemental oxygen. In addition, the company has granted emergency use authorization for 9 different COVID-19 remedies.

RELATED: Global COVID-19 death toll passes 3 million people

The medicine accredited for emergency use, delivered intravenously and made by Regeneron Pharmaceuticals and Eli Lily, have concentrated doses of lab-made antibodies to combat COVID-19 and are geared towards people who find themselves at excessive danger for extreme signs or having to be hospitalized.

Michigan will develop its use of COVID-19 remedy in the hopes of considerably lowering its rising numbers of hospitalizations and deaths, state officers introduced final week amid their efforts to carry down the nation’s highest an infection fee.

Gov. Gretchen Whitmer mentioned the Remdesivir remedy may save lives, including that it “very likely” helped then-President Donald Trump when he was contaminated final fall. People who qualify — an estimated 30% of contaminated residents — embrace seniors and people with preexisting or underlying health dangers.

According to Johns Hopkins, greater than 31 million Americans have tested constructive for COVID-19 because the pandemic started in March 2020. Since then, greater than 567,000 Americans have died from the virus.

RELATED: Half of US adults have now received at least one shot of COVID-19 vaccine, CDC says

Half of all adults in the U.S. have obtained not less than one COVID-19 shot, the federal government introduced Sunday, marking one other milestone in the nation’s largest-ever vaccination marketing campaign however leaving extra work to do to persuade skeptical Americans to roll up their sleeves.

Almost 130 million individuals 18 or older have obtained not less than one dose of a vaccine, or 50.4% of the full grownup inhabitants, the Centers for Disease Control and Prevention reported. Almost 84 million adults, or about 32.5% of the inhabitants, have been absolutely vaccinated.

The Associated Press and Megan Ziegler contributed to this report. This story was reported from Los Angeles.
 

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